By Ludwig Zirngibl
Azoles are valuable materials in lots of medicinal drugs. They play a tremendous function within the struggle opposed to epidermis deseases and the secondary indicators of AIDS. also they are utilized in the safety of crops and in (leather, wool, fibers). The fast improvement during this box gives a finished guide approximately their makes use of and applications.The publication covers the final 15 years of improvement of the name ingredients from a man-made natural standpoint in keeping with over 2700 references (including 1350 patents) until eventually October 1997. the writer indicates structure-activity relationships, actions and purposes. The paintings turns into an crucial making plans consultant for researchers within the pharmaceutical and at universities.
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Additional resources for Antifungal Azoles: A Comprehensive Survey of their Structures and Properties
49A has been replaced by heterocycles. 38 2 1-(Hydrogen-, alkyl-, aryl-, heterocyclyl-, arylalkyl-, heterocyclylalkyl-, ... 1). 361] Replacing phenyl B by pyrrol-3-yl, with phenyl C in pyrrol positions 1, 3 or 4, has arrived at optimal compounds with in vitro activities against Candida albicans and Candida spp. 59 displays better topical efficacy in experimental cutaneous candidiasis of rabbits than bifonazole. 60B. 54B. 367] Aspergillus, Malassezia furfur, and inhibits Corynebacterium minutissimum, Staphylococci, Streptococci which all may accompany mycotic infections.
It seems that addition of the dextrin may result in a better release of the drug from its preparations. 332] 34 2 1-(Hydrogen-, alkyl-, aryl-, heterocyclyl-, arylalkyl-, heterocyclylalkyl-, ... 333] The best example (Az = Im, n = 1, R, R¢, R† = Cl; R = Cl, R¢† = CH3) displays activity against Candida albicans and C. 333] Others inhibit Trichophyton mentagrophytes, Microsporum canis, and Aspergillus fumigatus. 334] They inhibit C. 336] Interesting activity against Piricularia oryzae on crops, fruit, vegetable and ornamental plants has been observed, and use for the protection of wood and varnishes has been proposed.
342] 36 2 1-(Hydrogen-, alkyl-, aryl-, heterocyclyl-, arylalkyl-, heterocyclylalkyl-, ... 55B, [129731-10-8] is hoped to present a new tool in the control of estrogen-dependent breast cancer. 52 with Ar2 = 1,4-benzoxazin-6-yl show bactericidal activity. ; their toxicity to Torulopsis glabrata, Rhodotorula spp. 23). 2 1-Di(heterocyclyl)methyl-1H-azoles One paper includes 1-[di(heterocyclyl)methyl]-1H-imidazoles. 49A has been replaced by heterocycles. 38 2 1-(Hydrogen-, alkyl-, aryl-, heterocyclyl-, arylalkyl-, heterocyclylalkyl-, ...
Antifungal Azoles: A Comprehensive Survey of their Structures and Properties by Ludwig Zirngibl