Applications of domino transformations in organic synthesis by Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon PDF

By Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon Boyce, Gaelle Blond, Iain Coldham

ISBN-10: 3132211419

ISBN-13: 9783132211414

ISBN-10: 3132211516

ISBN-13: 9783132211513

ISBN-10: 3132211710

ISBN-13: 9783132211711

ISBN-10: 3132211818

ISBN-13: 9783132211810

ISBN-10: 3132401633

ISBN-13: 9783132401631

The quick velocity of evolution in domino, or cascade-based changes has revolutionized the perform of chemical synthesis for the production of typical items, designed molecules, and pharmaceuticals.


"Science of Synthesis: purposes of Domino ameliorations in natural Synthesis" explores the subject completely and systematically, serving because the foundation for functional purposes and destiny study. The 2-volume set provides the state-of-the-art when it comes to layout, approach, and experimental strategies, resulting in a number of occasions being comprehensive inside of a unmarried response vessel. The content material is prepared by way of the center form of response used to begin the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.


Volume 2 covers pericyclic reactions (Diels-Alder, sigmatropic shifts, ene reactions), dearomatizations, and additions to C-O/C-N a number of bonds.

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439 419 Keyword Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 449 Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 481 Abbreviations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 The Diels–Alder Cycloaddition Reaction in the Context of Domino Processes J. G. West and E. J. Sorensen General Introduction The title that Otto Diels and Kurt Alder chose for their 1928 publication, “Syntheses in the Hydroaromatic Series”, in Annalen[1] did not signal the revolution that their new insights would bring to the field of organic chemistry.

5 h, the mixture was neutralized with sat. NaHCO3/Na2S2O3 and extracted with Et2O. 1 17 Diels–Alder Cycloaddition and concentrated under reduced pressure. 1H NMR analysis of the crude product showed 2H-pyran monomer 44, dimer 45A, and dimer 45B in a 1:1:1 ratio. 5 mg (41%)]. Endiandric Acid Methyl Esters 48–51:[44] When the acetylenic precursor 46 was mildly hydrogenated (H2, Lindlar catalyst, quinoline, CH2Cl2, 25 8C) followed by brief heating of the resulting mixture at 100 8C (toluene), endiandric acid methyl esters 48–51 were produced and chromatographically isolated.

3 Lewis Acid Catalyzed Domino Addition to C=O Bonds . . . . . . . . . . . 4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Additions to C=N Bonds and Nitriles E. Kroon, T. Zarganes Tzitzikas, C. G. Neochoritis, and A. 4 Additions to C=N Bonds and Nitriles . . . . . . . . . . . . . . . . . . . 1 Addition to C=N Bonds and the Pictet–Spengler Strategy . . . . . . . . . . 2 Ugi Five-Center Four-Component Reaction Followed by Postcondensations .

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Applications of domino transformations in organic synthesis 2 by Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon Boyce, Gaelle Blond, Iain Coldham


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