Mariko Morishita, Kinam Park's Biodrug Delivery Systems: Fundamentals, Applications and PDF

By Mariko Morishita, Kinam Park

ISBN-10: 1420086685

ISBN-13: 9781420086683

Biodrug supply structures: basics, purposes and medical Development provides the paintings of a global staff of top specialists in drug improvement and biopharmaceutical technology who speak about the newest advances in biodrug supply platforms and linked concepts. The publication discusses elements of profitable formula, supply, and construction of biodrugs, which come with subtle crops and intricate methods, a well-trained and an expert employees, and correct quality controls. moreover, the authors examine:

  • ADME (Absorption, Metabolism, Distribution, and removing of biodrugs)
  • Directing and influencing the winning improvement of presently advertised best-selling biodrugs
  • Routes of management
  • Mechanisms of biodrug absorption
  • Alternative probabilities for drug supply routes
  • Formulationson the marketplace from the viewpoint of body of workers keen on biodrug development

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Extra resources for Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development (Drugs and the Pharmaceutical Sciences)

Example text

It is an equilibrium between the folded native (N) and the disordered, unfolded or denatured (D) species. An intermediate step, the formation of possible intermediates (I), can be present between the transformation from N to D. The aggregate (A) formation may occur due to irreversible changes in the unfolded species, and it can result in formations of fibrils (F). Aggregation is a term used to describe either soluble or insoluble protein assemblies caused by either covalent or noncovalent interactions.

Ensuring appropriate deposition at the site of absorption often requires specific formulation strategies such as a proper aerodynamic diameter of particles for pulmonal delivery (8) or enterocoating and also mucoadhesiveness of drug delivery systems for oral and mucosal delivery (9–11). Protection against enzymatic degradation by particulate encapsulation (4) and/or coadministration of competitive enzyme inhibitors will for most routes of delivery be advantageous despite the differences in proteolytic activities.

Issues in Development of Biodrug Delivery Systems 19 BIOLOGICAL ACTIVITY AND IMMUNOGENICITY For many peptide and proteins, another major issue is the retention of biological activity and the potential of developing immunogenicity toward either the drug itself or components in the drug delivery system (52). The effects are often observed as the development of neutralizing antibodies or autoimmunogenicity leading to detectable adverse effects. Furthermore, it results in inactivation and a faster clearance of the drug and thus a reduction of the activity of the drug.

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Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development (Drugs and the Pharmaceutical Sciences) by Mariko Morishita, Kinam Park

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